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Common names: Etizolam, "Etilaam", "Etizest"
Substitutive name: Etizolam
Systematic name: 4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
Psychoactive class: Depressant

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Etizolam (also known by the trade names Etilaam, Etizest, among many others) is a synthetic, fast-acting depressant substance of the thienodiazepine chemical class that produces benzodiazepine-like anxiety suppressing, disinhibiting, muscle relaxing, sedating, and memory suppressing effects when administered. Etizolam is commonly administered orally and sublingually due to the efficiency of these routes.

Etizolam is not commonly prescribed and is not recognized as a controlled substance in many parts of the world, which has led to its rise as a popular research chemical substitute for pharmaceutical benzodiazepines, typically those that are sought after for their recreational effects. It is commonly found in pellet or pill form, laid on a blotter sheet, or as a powder

It should be noted that that as with benzodiazepines, the sudden discontinuation of thienodiazepines can be potentially dangerous or even life-threatening for individuals who have been using the substance regularly for extended periods of time, as it can result in fatal seizures. As a result, individuals who find themselves physically dependent on this substance are highly advised to taper their dose by gradually lowering the amount taken each day over a prolonged period of time instead of stopping their intake abruptly.

Due to the high dependence-forming and addiction potential that this substance shares with members of the closely related benzodiazepine class, as well as its alcohol-like ability to induce dangerous disinhibitory black-out states, it is highly advised to use proper harm reduction practices if choosing to use this substance.

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*Chemistry
Etizolam is a structural relative of benzodiazepines, whereby the benzene ring has been replaced by a thiophene ring, classifying it as a thienodiazepine. Thiophene is a five membered aromatic ring with one sulfur atom. Etizolam contains a thiophene ring fused to a diazepine ring, which is a seven membered ring with the two nitrogen constituents located at R1 and R4. This forms the thienodiazepine core of etizolam. An ethyl chain is bound to this bicyclic structure at R7. Additionally, a R2' chlorine-substituted phenyl ring is bound to this structure at R5.

Etizolam also contains a methylated triazole ring fused to and incorporating R1 and R2 of its diazepine ring. Etizolam shares this fused triazole ring substitution with certain benzodiazepine drugs, called triazolobenzodiazepines, distinguished by the suffix "-zolam".

*Pharmacology
Thienodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors.[5] As this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects) of etizolam on the nervous system.

*Subjective effects
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

*Physical effects
-Sedation - In terms of energy level alterations, this substance has the potential to become very sedating in a rapid-acting fashion. At higher doses, this can lead users to suddenly feel as if they are extremely sleep deprived and have not slept for days, forcing them to sit down and generally feel as if they are constantly on the verge of passing out instead of engaging in physical activities. This sense of sleep deprivation increases proportional to dosage and eventually becomes powerful enough to force a person into complete unconsciousness.
-Muscle relaxation
-Physical euphoria
-Motor control loss
-Respiratory depression
-Increased libido
-Seizure suppression
-Appetite enhancement - This effect is not particularly prominent, but is reported to occur in some people. It can have a synergistic effect when combined with cannabis.
-Dizziness
-Temporary erectile dysfunction
-Paradoxical effects
*Note: The following references benzodiazepines specifically, but due to the close structural and pharmacological similarities they share, can be taken to apply to thienodiazepines like etizolam as well.

Paradoxical reactions to benzodiazepines such as increased seizures (in epileptics), aggression, increased anxiety, violent behavior, loss of impulse control, irritability and suicidal behavior sometimes occur (although they are rare in the general population, with an incidence rate below 1%).
These paradoxical effects occur with greater frequency in recreational abusers, individuals with mental disorders, children, and patients on high-dosage regimes.

*Cognitive effects
-Anxiety suppression
-Disinhibition
-Cognitive euphoria - This effect is generally produced only at high doses, and is thought to arise largely from the release of pre-existing anxiety in the user. Many users report not feeling any pleasurable or euphoric sensations from benzodiazepines or thienodiazepines like etizolam at all.
-Compulsive redosing - This component is likely due to the rapid way in which the substance produces its anxiety-relieving, relaxing and sometimes euphoric effects before quickly dropping off. It can be made worse due to the memory suppression it produces which can lead the user forgetting they have taken any at all, which can lead to a cycle that leads to a dangerous amnesic blackout state.
-Ego inflation
-Thought deceleration
-Motivation suppression
-Emotionality suppression - Although this compound primarily suppresses anxiety, it also dulls other emotions in a manner which is distinct but less intensive than that of antipsychotics.
-Sleepiness

*After effects
-Rebound anxiety - Rebound anxiety is a commonly observed effect with anxiety relieving substances like benzodiazepines and etizolam. It typically corresponds to the total duration spent under the substance's influence along with the total amount consumed in a given period, an effect which can easily lend itself to cycles of dependence and addiction.
-Dream potentiation or Dream suppression
-Residual sleepiness - While etizolam can be used as an effective sleep-inducing aid, its effects may persist into the morning afterwards, which may lead users to feeling "groggy" or "dull" for up to a few hours.
-Thought deceleration
-Thought disorganization
-Irritability

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Buy Etizolam Pellets

Buy Etizolam Pellets

Common names: Etizolam, "Etilaam", "Etizest"
Substitutive name: Etizolam
Systematic name: 4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
Psychoactive class: Depressant

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  • Description: Common names: Etizolam, "Etilaam", "Etizest" Substitutive name: Etizolam Systematic name: 4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine Psychoactive class: Depressant Customers also showed interest in the products Synthacaine Research Chemical NM2AI & MPA Pellets Camfetamine Research Chemical MDPV Research Chemical
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